La tercera parte del simulador musical de Activision y Neversoft significó un importante salto cualitativo en la serie, con novedades en los modos y sobre todo un equilibrado listado de temas (Tracklist), que incluye en su repertorio a AFI, Guns N'Roses, Kiss, Metallica, The Killers o Muse.
Lista completa de canciones de Guitar Hero Legends of Rock:
- Queens of the Stone Age - "3's & 7's"
- The Sex Pistols - "Anarchy in the UK"
- Heart - "Barracuda"
- Slipknot - "Before I Forget"
- Santana - "Black Magic Woman"
- White Zombie - "Black Sunshine"
- Rage Against the Machine - "Bulls on Parade"
- The Smashing Pumpkins - "Cherub Rock"
- Blue Öyster Cult - "Cities on Flame with Rock and Roll"
- Eric Johnson - "Cult of Personality"
- Steve Ouimette - "The Devil Went Down to Georgia"
- Pearl Jam - "Even Flow"
- Slash - Guitar Battle vs. Slash
- Tom Morello - Guitar Battle vs. Tom Morello
- Bloc Party - "Helicopter"
- Pat Benatar - "Hit me with your best shot"
- Dead Kennedys - "Holiday in Cambodia"
- Muse - "Knights of Cydonia"
- Sonic Youth - "Kool Thing"
- ZZ Top - "La Grange"
- Priestess - "Lay Down"
- Tenacious D - "The Metal"
- AFI - "Miss Murder"
- Mountain - "Mississipi Queen"
- Matchbook Romance - "Monsters"
- Weezer - "My name is Jonas"
- Iron Maiden - "The Number of the Beast"
- Metallica - "One"
- The Rolling Stones - "Paint it Black"
- Black Sabbath - "Paranoid"
- Stevie Ray Vaughan - "Pride and Joy"
- Slayer - "Raining Blood"
- The Strokes - "Reptilia"
- Kiss - "Rock and Roll All Nite"
- Scorpions - "Rock You Like a Hurrican"
- Beastie Boys - "Sabotage"
- Aerosmith - "Same Old Song and Dance"
- Alice Cooper - "School's Out"
- The Who - "The Seeker"
- Foghat - "slow Ride"
- Social Distortion - "Story of My Life"
- Disturbed - "Stricken"
- Red Hot Chili Peppers - "Suck My Kiss"
- Cream - "Sunshine of your Love"
- Poison - "Talk Dirty to me"
- Guns N'Roses - "Welcome to the Jungle"
- The Killers - "When you were Young"
Además el juego incluye una serie de canciones bonus que se irán desbloqueando.